Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.11 (overall 0.07) | 0.11 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3898
Sealed predictions
- NCKIPSD in dopamine neurons, braak-0.63 (p 0.068) → +0.04 (p 0.912)receipt 3906
Swarm cases
receipt 3906: NCKIPSD in dopamine neurons, braak
- power
- full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.074, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.099, n 18). could be the mix.
- skeptic
- leave-one-out range -0.56 to -0.34, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NCKIPSD in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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