parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.24 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in platelets	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 121	0.85
pathways Reactome	8 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 1790

receipt 1799: NCK2 in dopamine neurons, braak

power: full sample -0.20 (p 0.434, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.16 (p 0.526, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.37 (p 0.130, n 18). could be the mix.
skeptic: leave-one-out range -0.35 to -0.09, sign flips 0; without severely affected donors -0.20 (p 0.434, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NCK2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1798: NCK2 in microglia, braak

power: full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.05 (p 0.847, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
skeptic: leave-one-out range -0.21 to +0.05, sign flips 3; without severely affected donors -0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NCK2 in microglia.

case closed: nothing better to follow up.

loading the receipts