parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in lactotrophs	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 99	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 10501

receipt 10509: NAV3 in dopamine neurons, braak

power: full sample +0.15 (p 0.561, n 18), 95% CI -0.34 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.696, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.10 (p 0.702, n 18). could be the mix.
skeptic: leave-one-out range +0.07 to +0.31, sign flips 0; without severely affected donors +0.15 (p 0.561, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NAV3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10508: NAV3 in microglia, braak

power: full sample +0.33 (p 0.176, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.41 (p 0.093, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.50 (p 0.036, n 18). not the mix.
skeptic: leave-one-out range +0.25 to +0.45, sign flips 0; without severely affected donors +0.33 (p 0.176, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NAV3 in microglia.

case closed: nothing better to follow up.

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