Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.18 (overall 0.11) | 0.18 |
| cell type Human Protein Atlas | cell type enriched outside the brain (myonuclei) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 61 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2442
Sealed predictions
- MYLK2 in dopamine neurons, braak-0.25 (p 0.520) → -0.34 (p 0.373)receipt 2449
Swarm cases
receipt 2449: MYLK2 in dopamine neurons, braak
- power
- full sample -0.23 (p 0.351, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.408, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.294, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.351, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MYLK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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