Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 26 Parkinson's trials, 2 stopped | 0.94 |
| literature PubMed | 24 Parkinson's papers of 3,210 | 0.58 |
| pathways Reactome | 6 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 7131
Sealed predictions
- MTR in dopamine neurons, braak+0.64 (p 0.063) → -0.28 (p 0.473)receipt 7138
Swarm cases
receipt 7138: MTR in dopamine neurons, braak
- power
- full sample +0.10 (p 0.696, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.741, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.05 (p 0.834, n 18). could be the mix.
- skeptic
- leave-one-out range -0.04 to +0.21, sign flips 1; without severely affected donors +0.10 (p 0.696, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MTR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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