Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.49 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: perhexiline, ds-7423, cc-115 +23 | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 688 Parkinson's papers of 63,472: well-trodden | 0.14 |
| pathways Reactome | 15 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 0254
Sealed predictions
- MTOR in dopamine neurons, braak-0.07 (p 0.849) → +0.23 (p 0.554)receipt 0260
Swarm cases
receipt 0260: MTOR in dopamine neurons, braak
- power
- full sample +0.16 (p 0.538, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.17 (p 0.509, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.16 (p 0.538, n 18). could be the mix.
- skeptic
- leave-one-out range +0.05 to +0.28, sign flips 0; without severely affected donors +0.16 (p 0.538, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MTOR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts