parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.40 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in renal connecting tubule cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly vesicle traffic	1.00

No case: the score is under the bar. Receipt 0639

MTMR10 in oligodendrocytes, braak+0.45 (p 0.219) → +0.86 (p 0.003)receipt 0646
MTMR10 in dopamine neurons, braak+0.14 (p 0.725) → +0.49 (p 0.183)receipt 0647

receipt 0647: MTMR10 in dopamine neurons, braak

power: full sample +0.20 (p 0.418, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.21 (p 0.393, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.21 (p 0.413, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.35, sign flips 0; without severely affected donors +0.20 (p 0.418, n 18). fragile.
cell type: strongest in oligodendrocytes: +0.60 (p 0.0083, n 18) vs +0.20 in dopamine neurons. proposing oligodendrocytes.
axis: no measure beats "tracks Braak Lewy-body stage" for MTMR10 in dopamine neurons.

case closed: every proposal failed a challenge.

receipt 0646: MTMR10 in oligodendrocytes, braak

power: full sample +0.60 (p 0.0083, n 18), 95% CI +0.19 to +0.83. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.55 (p 0.018, n 18). holds up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.42 (p 0.080, n 18). could be the mix.
skeptic: leave-one-out range +0.55 to +0.81, sign flips 0; without severely affected donors +0.60 (p 0.0083, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MTMR10 in oligodendrocytes.

case closed: nothing better to follow up.

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