Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 34 Parkinson's trials, 5 stopped | 0.88 |
| literature PubMed | 118 Parkinson's papers of 5,463 | 0.37 |
| pathways Reactome | 5 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 9979
Sealed predictions
- MSN in dopamine neurons, braak+0.05 (p 0.894) → -0.23 (p 0.549)receipt 9986
Swarm cases
receipt 9986: MSN in dopamine neurons, braak
- power
- full sample -0.10 (p 0.702, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.09 (p 0.735, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.03, sign flips 1; without severely affected donors -0.10 (p 0.702, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MSN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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