Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in proximal tubule cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 18 | 0.91 |
| pathways Reactome | 1 pathway; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 15712
Sealed predictions
- MRM1 in dopamine neurons, braak-0.47 (p 0.202) → -0.37 (p 0.334)receipt 15721
Swarm cases
receipt 15721: MRM1 in dopamine neurons, braak
- power
- full sample -0.13 (p 0.603, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.19 (p 0.450, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to -0.02, sign flips 0; without severely affected donors -0.13 (p 0.603, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MRM1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts