Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.35 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 0909
Sealed predictions
- MPRIP in dopamine neurons, braak-0.67 (p 0.049) → +0.32 (p 0.407)receipt 0917
Swarm cases
receipt 0917: MPRIP in dopamine neurons, braak
- power
- full sample -0.30 (p 0.225, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.221, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.063, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.21, sign flips 0; without severely affected donors -0.30 (p 0.225, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.60 (p 0.0080, n 18) vs -0.30 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MPRIP in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up MPRIP · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.30 p 0.286 (needs p < 0.0014)
Receipts
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