Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in pituitary stem cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14796
Sealed predictions
- MPPED2 in dopamine neurons, braak+0.06 (p 0.886) → +0.55 (p 0.122)receipt 14805
- MPPED2 in oligodendrocytes, braak-0.31 (p 0.414) → +0.08 (p 0.838)receipt 14804
Swarm cases
receipt 14805: MPPED2 in dopamine neurons, braak
- power
- full sample +0.20 (p 0.429, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.20 (p 0.429, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.814, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.31, sign flips 0; without severely affected donors +0.20 (p 0.429, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MPPED2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 14804: MPPED2 in oligodendrocytes, braak
- power
- full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.16 (p 0.526, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.01, sign flips 3; without severely affected donors -0.11 (p 0.671, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MPPED2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts