Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8517
Sealed predictions
- MPP1 in dopamine neurons, braak+0.74 (p 0.024) → +0.00 (p 1.000)receipt 8525
Swarm cases
receipt 8525: MPP1 in dopamine neurons, braak
- power
- full sample +0.35 (p 0.153, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.44 (p 0.064, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.050, n 18). not the mix.
- skeptic
- leave-one-out range +0.27 to +0.48, sign flips 0; without severely affected donors +0.35 (p 0.153, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MPP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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