Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (submucosal glandular cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: doxycycline, doxycycline hyclate, marimastat | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 3 Parkinson's papers of 3,498 | 0.82 |
| pathways Reactome | 5 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 3506
Sealed predictions
- MMP7 in dopamine neurons, braak+0.45 (p 0.230) → +0.32 (p 0.400)receipt 3514
Swarm cases
receipt 3514: MMP7 in dopamine neurons, braak
- power
- full sample +0.41 (p 0.095, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.48 (p 0.042, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.042, n 18). not the mix.
- skeptic
- leave-one-out range +0.33 to +0.55, sign flips 0; without severely affected donors +0.41 (p 0.095, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MMP7 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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