Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (cardiomyocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 23 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 74 Parkinson's papers of 21,717 | 0.43 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 16574
Sealed predictions
- MIP in dopamine neurons, braak+0.70 (p 0.034) → -0.61 (p 0.078)receipt 16582
Swarm cases
receipt 16582: MIP in dopamine neurons, braak
- power
- full sample -0.21 (p 0.403, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.444, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.332, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.10, sign flips 0; without severely affected donors -0.21 (p 0.403, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MIP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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