Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: amg-548, ph-797804, azd-7624 +25 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 9 Parkinson's papers of 1,249 | 0.70 |
| pathways Reactome | 18 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 1144
Sealed predictions
- MAPK14 in dopamine neurons, braak-0.60 (p 0.090) → +0.19 (p 0.631)receipt 1150
Swarm cases
receipt 1150: MAPK14 in dopamine neurons, braak
- power
- full sample -0.13 (p 0.621, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.393, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.393, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to -0.01, sign flips 0; without severely affected donors -0.13 (p 0.621, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAPK14 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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