Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 279 | 0.82 |
| pathways Reactome | 3 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 10400
Sealed predictions
- MAPK13 in dopamine neurons, braak-0.57 (p 0.109) → -0.20 (p 0.607)receipt 10407
Swarm cases
receipt 10407: MAPK13 in dopamine neurons, braak
- power
- full sample -0.46 (p 0.052, n 18), 95% CI -0.77 to +0.00. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.077, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.0096, n 18). not the mix.
- skeptic
- leave-one-out range -0.56 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.052, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAPK13 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts