Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4391
Sealed predictions
- MAP3K3 in dopamine neurons, braak+0.37 (p 0.329) → -0.29 (p 0.449)receipt 4399
Swarm cases
receipt 4399: MAP3K3 in dopamine neurons, braak
- power
- full sample -0.14 (p 0.585, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.04 (p 0.874, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to -0.02, sign flips 0; without severely affected donors -0.14 (p 0.585, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAP3K3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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