Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: cep-1347 | 0.90 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 1 stopped | 0.73 |
| literature PubMed | 2 Parkinson's papers of 59 | 0.85 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2792
Sealed predictions
- MAP3K12 in dopamine neurons, braak+0.02 (p 0.962) → -0.26 (p 0.493)receipt 2798
Swarm cases
receipt 2798: MAP3K12 in dopamine neurons, braak
- power
- full sample -0.17 (p 0.504, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.16 (p 0.532, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.315, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.06, sign flips 0; without severely affected donors -0.17 (p 0.504, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAP3K12 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts