Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: cep-1347 | 0.90 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 1 stopped | 0.73 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 7 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 1134
Sealed predictions
- MAP3K11 in dopamine neurons, braak-0.32 (p 0.402) → -0.26 (p 0.498)receipt 1140
Swarm cases
receipt 1140: MAP3K11 in dopamine neurons, braak
- power
- full sample -0.36 (p 0.148, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.36 (p 0.148, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.118, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.27, sign flips 0; without severely affected donors -0.36 (p 0.148, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAP3K11 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts