Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: cep-1347 | 0.90 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 1 stopped | 0.73 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2719
Sealed predictions
- MAP3K10 in dopamine neurons, braak-0.50 (p 0.172) → -0.72 (p 0.030)receipt 2726
Swarm cases
receipt 2726: MAP3K10 in dopamine neurons, braak
- power
- full sample -0.59 (p 0.0099, n 18), 95% CI -0.83 to -0.17. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.62 (p 0.0060, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0062, n 18). not the mix.
- skeptic
- leave-one-out range -0.68 to -0.54, sign flips 0; without severely affected donors -0.59 (p 0.0099, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MAP3K10 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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