Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

MAOB

monoamine oxidase B

translation score 0.38, read 2026-10-27; 3 sealed predictions, 1 held; 14 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.63 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including other brain neurons; strongest in myonuclei0.75
chemistry
Open Targets		compounds already reach it: phenelzine sulfate, selegiline, mebanazine +141.00
trials
ClinicalTrials.gov		25 Parkinson's trials, 1 stopped0.97
literature
PubMed		1,351 Parkinson's papers of 4,146: well-trodden0.05
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 11449

Earlier readings: 2026-10-26 0.38; 2026-10-25 0.38; 2026-10-24 0.38; 2026-10-23 0.38.

Sealed predictions

  1. MAOB in dopamine neurons, braak+0.70 (p 2.5e-7) → +0.53 (p 2.8e-4)held
  2. MAOB in dopamine neurons, braak+0.24 (p 0.539) → +0.67 (p 0.048)receipt 0540
  3. MAOB in dopamine neurons, resilience-0.48 (p 0.138) → -0.03 (p 0.902)receipt 0053

Swarm cases

receipt 0540: MAOB in dopamine neurons, braak

power
full sample +0.35 (p 0.150, n 18), 95% CI -0.14 to +0.70. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.49 (p 0.037, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.45 (p 0.062, n 18). could be the mix.
skeptic
leave-one-out range +0.27 to +0.46, sign flips 0; without severely affected donors +0.35 (p 0.150, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MAOB in dopamine neurons.

case closed: nothing better to follow up.

receipt 0053: MAOB in dopamine neurons, resilience

power
full sample -0.17 (p 0.388, n 55), 95% CI -0.42 to +0.10. the interval is wide: not enough donors to tell.
confounder
adjusted for age, sex and PMI: -0.14 (p 0.474, n 55). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.06 (p 0.752, n 55). could be the mix.
skeptic
leave-one-out range -0.28 to -0.09, sign flips 0; without severely affected donors -0.10 (p 0.634, n 46). fragile.
cell type
no other cell group does better.
axis
braak beats resilience for MAOB in dopamine neurons: +0.65 (p 3.3e-11, n 84). proposing braak.

case closed: every proposal failed a challenge.

Receipts

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