Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.93 (overall 0.88) | 0.93 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 51 Parkinson's trials, 7 stopped | 0.89 |
| literature PubMed | 3,655 Parkinson's papers of 4,082: well-trodden | 0.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11443
Earlier readings: 2026-10-26 0.54; 2026-10-26 0.54; 2026-10-25 0.54; 2026-10-24 0.54.
Sealed predictions
- LRRK2 in dopamine neurons, resilience+0.00 (p 1.000) → +0.00 (p 1.000)receipt 10876
- LRRK2 in microglia, braak+0.23 (p 0.545) → +0.29 (p 0.443)receipt 10874
- LRRK2 in dopamine neurons, braak+0.95 (p 9.6e-5) → -0.05 (p 0.893)receipt 0506
- LRRK2 in dopamine neurons, resilience+0.05 (p 0.871) → -0.23 (p 0.389)receipt 0003
- LRRK2 in dopamine neurons, braak+0.03 (p 0.863) → -0.06 (p 0.714)receipt 0002
In the sealed studies
- The lysosomal axis in dopamine neurons: did not hold
Swarm cases
receipt 0506: LRRK2 in dopamine neurons, braak
- power
- full sample +0.44 (p 0.070, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.41 (p 0.091, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.114, n 18). could be the mix.
- skeptic
- leave-one-out range +0.35 to +0.64, sign flips 0; without severely affected donors +0.44 (p 0.070, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRRK2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0003: LRRK2 in dopamine neurons, resilience
- power
- full sample -0.12 (p 0.556, n 55), 95% CI -0.37 to +0.15. the interval is wide: not enough donors to tell.
- confounder
- adjusted for age, sex and PMI: -0.11 (p 0.570, n 55). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: -0.11 (p 0.570, n 55). could be the mix.
- skeptic
- leave-one-out range -0.22 to -0.04, sign flips 0; without severely affected donors -0.14 (p 0.495, n 46). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for LRRK2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 0002: LRRK2 in dopamine neurons, braak
- power
- full sample +0.00 (p 0.999, n 84), 95% CI -0.21 to +0.21. the interval sits on zero: probably nothing there.
- confounder
- adjusted for age, sex and PMI: +0.02 (p 0.882, n 84). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis -0.72 (p 1.8e-14); controlling for it: +0.02 (p 0.882, n 84). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.03, sign flips 47; without severely affected donors +0.07 (p 0.543, n 75). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LRRK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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