parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (644 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	43 Parkinson's papers of 119	0.50
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 3819

receipt 3827: LRRK1 in dopamine neurons, braak

power: full sample -0.45 (p 0.059, n 18), 95% CI -0.76 to +0.02. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.46 (p 0.056, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.65 (p 0.0036, n 18). not the mix.
skeptic: leave-one-out range -0.54 to -0.38, sign flips 0; without severely affected donors -0.45 (p 0.059, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LRRK1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3826: LRRK1 in microglia, braak

power: full sample -0.36 (p 0.140, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.36 (p 0.137, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.21 (p 0.393, n 18). could be the mix.
skeptic: leave-one-out range -0.54 to -0.29, sign flips 0; without severely affected donors -0.36 (p 0.140, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LRRK1 in microglia.

case closed: nothing better to follow up.

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