parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in distal convoluted tubule cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 29	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 14810

LRCH1 in microglia, braak-0.16 (p 0.685) → +0.44 (p 0.237)receipt 14817
LRCH1 in dopamine neurons, braak-0.15 (p 0.699) → -0.12 (p 0.767)receipt 14818

receipt 14818: LRCH1 in dopamine neurons, braak

power: full sample -0.10 (p 0.683, n 18), 95% CI -0.54 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.735, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to +0.01, sign flips 2; without severely affected donors -0.10 (p 0.683, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LRCH1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 14817: LRCH1 in microglia, braak

power: full sample +0.15 (p 0.544, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.15 (p 0.544, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.16 (p 0.515, n 18). could be the mix.
skeptic: leave-one-out range +0.05 to +0.27, sign flips 0; without severely affected donors +0.15 (p 0.544, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LRCH1 in microglia.

case closed: nothing better to follow up.

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