parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in foveolar cells	0.75
chemistry Open Targets	hard to drug	0.27
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	4 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 4047

receipt 4055: LPIN2 in dopamine neurons, braak

power: full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.36 (p 0.148, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.254, n 18). could be the mix.
skeptic: leave-one-out range -0.55 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LPIN2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4054: LPIN2 in microglia, braak

power: full sample +0.14 (p 0.591, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.12 (p 0.646, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.11 (p 0.658, n 18). could be the mix.
skeptic: leave-one-out range +0.02 to +0.28, sign flips 0; without severely affected donors +0.14 (p 0.591, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LPIN2 in microglia.

case closed: nothing better to follow up.

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