Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 98 Parkinson's trials, 6 stopped | 0.90 |
| literature PubMed | 82 Parkinson's papers of 14,439 | 0.42 |
| pathways Reactome | 4 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4784
Sealed predictions
- LBP in dopamine neurons, braak-0.68 (p 0.042) → -0.03 (p 0.946)receipt 4791
Swarm cases
receipt 4791: LBP in dopamine neurons, braak
- power
- full sample -0.30 (p 0.221, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.32 (p 0.198, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.031, n 18). not the mix.
- skeptic
- leave-one-out range -0.41 to -0.22, sign flips 0; without severely affected donors -0.30 (p 0.221, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LBP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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