parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in proximal tubule cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	14 Parkinson's trials, 0 stopped	1.00
literature PubMed	17 Parkinson's papers of 5,415	0.62
pathways Reactome	7 pathways; mostly growth signalling	0.60

No case: the score is under the bar. Receipt 11660

receipt 11668: LAT in dopamine neurons, braak

power: full sample -0.01 (p 0.976, n 18), 95% CI -0.47 to +0.46. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.949, n 18). could be the mix.
skeptic: leave-one-out range -0.15 to +0.13, sign flips 8; without severely affected donors -0.01 (p 0.976, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LAT in dopamine neurons.

case closed: nothing better to follow up.

receipt 11667: LAT in astrocytes, braak

power: full sample -0.24 (p 0.337, n 18), 95% CI -0.64 to +0.26. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.22 (p 0.383, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.37 (p 0.135, n 18). could be the mix.
skeptic: leave-one-out range -0.39 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.337, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for LAT in astrocytes.

case closed: nothing better to follow up.

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