Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody: ocriplasmin | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 13 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 4349
Sealed predictions
- LAMC1 in dopamine neurons, braak-0.06 (p 0.874) → +0.58 (p 0.102)receipt 4356
Swarm cases
receipt 4356: LAMC1 in dopamine neurons, braak
- power
- full sample +0.36 (p 0.140, n 18), 95% CI -0.13 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.049, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.53 (p 0.022, n 18). not the mix.
- skeptic
- leave-one-out range +0.29 to +0.49, sign flips 0; without severely affected donors +0.36 (p 0.140, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LAMC1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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