Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody: ocriplasmin | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 248 | 0.82 |
| pathways Reactome | 10 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8898
Sealed predictions
- LAMB2 in dopamine neurons, braak-0.66 (p 0.054) → -0.69 (p 0.042)receipt 8906
Swarm cases
receipt 8906: LAMB2 in dopamine neurons, braak
- power
- full sample -0.64 (p 0.0044, n 18), 95% CI -0.85 to -0.24. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.69 (p 0.0015, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.76 (p 2.5e-4, n 18). not the mix.
- skeptic
- leave-one-out range -0.77 to -0.59, sign flips 0; without severely affected donors -0.64 (p 0.0044, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for LAMB2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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