Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

KLRK1

killer cell lectin like receptor K1

translation score 0.59, read 2026-10-21; 2 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.04 from other evidence0.00
cell type
Human Protein Atlas		group enriched in oligodendrocyte progenitor cells (25 nCPM)1.00
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		2 Parkinson's papers of 1580.85
pathways
Reactome		3 pathways; mostly immune signalling0.90
proposal for KLRK1, translation score 0.59

Knock down and overexpress KLRK1 in oligodendrocytes; measure IL-1β and TNF release and surface HLA-DR and α-synuclein uptake and myelin basic protein output under oxidative stress.

Cell type
oligodendrocytes
Direction
Both arms: public data does not say which way helps.
Molecular readout
IL-1β and TNF release and surface HLA-DR
Functional readout
α-synuclein uptake and myelin basic protein output under oxidative stress
Rule-out
If neither arm moves IL-1β by 20% or more against non-targeting and empty-vector controls, across three independent differentiations, the hypothesis is wrong.
Lab request
CRISPRi knockdown and lentiviral overexpression of KLRK1 in iPSC-derived oligodendrocytes; n = 3 differentiations; readouts: IL-1β and TNF release and surface HLA-DR; α-synuclein uptake and myelin basic protein output under oxidative stress. Controls: non-targeting guide, empty vector. About 8 to 10 weeks, most of it differentiation.

Sealed predictions

  1. KLRK1 in dopamine neurons, braak-0.79 (p 0.011) → -0.25 (p 0.514)receipt 5833
  2. KLRK1 in oligodendrocytes, braakn/a → n/areceipt 5832

Swarm cases

receipt 5833: KLRK1 in dopamine neurons, braak

power
full sample -0.43 (p 0.072, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.38 (p 0.118, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.34 (p 0.167, n 18). could be the mix.
skeptic
leave-one-out range -0.65 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.072, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KLRK1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5832: KLRK1 in oligodendrocytes, braak

cell type
KLRK1 is not measured in oligodendrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KLRK1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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