Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | enriched in the midbrain (70 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 29 | 0.82 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5327
Sealed predictions
- KLHL1 in dopamine neurons, braak+0.84 (p 0.004) → -0.20 (p 0.602)receipt 5333
Swarm cases
receipt 5333: KLHL1 in dopamine neurons, braak
- power
- full sample +0.43 (p 0.074, n 18), 95% CI -0.04 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.072, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.42 (p 0.082, n 18). could be the mix.
- skeptic
- leave-one-out range +0.35 to +0.64, sign flips 0; without severely affected donors +0.43 (p 0.074, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KLHL1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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