Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.45 (overall 0.29) | 0.45 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 56 Parkinson's papers of 5,415 | 0.47 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1332
Sealed predictions
- KLF4 in dopamine neurons, braak-0.26 (p 0.493) → -0.80 (p 0.010)receipt 1340
Swarm cases
receipt 1340: KLF4 in dopamine neurons, braak
- power
- full sample -0.37 (p 0.130, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.35 (p 0.156, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.013, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.130, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KLF4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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