Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

KCNT2

potassium sodium-activated channel subfamily T member 2

translation score 0.45, read 2026-10-31; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in epicardial cells0.75
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 530.91
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 16695

Sealed predictions

  1. KCNT2 in oligodendrocytes, braak+0.28 (p 0.464) → -0.26 (p 0.493)receipt 16704
  2. KCNT2 in dopamine neurons, braak+0.69 (p 0.038) → +0.08 (p 0.838)receipt 16705

Swarm cases

receipt 16705: KCNT2 in dopamine neurons, braak

power
full sample +0.42 (p 0.084, n 18), 95% CI -0.06 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.40 (p 0.101, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.107, n 18). could be the mix.
skeptic
leave-one-out range +0.34 to +0.62, sign flips 0; without severely affected donors +0.42 (p 0.084, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNT2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16704: KCNT2 in oligodendrocytes, braak

power
full sample +0.05 (p 0.840, n 18), 95% CI -0.43 to +0.51. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.01 (p 0.969, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic
leave-one-out range -0.01 to +0.20, sign flips 5; without severely affected donors +0.05 (p 0.840, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNT2 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

loading the receipts