Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

KCNMA1

potassium calcium-activated channel subfamily M alpha 1

translation score 0.52, read 2026-10-19; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.08 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in retinal bipolar cells0.75
chemistry
Open Targets		compounds already reach it: bms-223131, andolast, flindokalner0.90
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		3 Parkinson's papers of 3960.82
pathways
Reactome		4 pathways; mostly other0.30

No case: the score is under the bar. Receipt 3370

Sealed predictions

  1. KCNMA1 in dopamine neurons, braak-0.78 (p 0.013) → +0.00 (p 1.000)receipt 3377
  2. KCNMA1 in oligodendrocytes, braak-0.15 (p 0.702) → -0.08 (p 0.840)receipt 3376

Swarm cases

receipt 3377: KCNMA1 in dopamine neurons, braak

power
full sample -0.24 (p 0.328, n 18), 95% CI -0.64 to +0.25. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.24 (p 0.328, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.56 (p 0.015, n 18). not the mix.
skeptic
leave-one-out range -0.35 to -0.15, sign flips 0; without severely affected donors -0.24 (p 0.328, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNMA1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3376: KCNMA1 in oligodendrocytes, braak

power
full sample -0.20 (p 0.424, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.15 (p 0.555, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.32 (p 0.194, n 18). could be the mix.
skeptic
leave-one-out range -0.30 to -0.10, sign flips 0; without severely affected donors -0.20 (p 0.424, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNMA1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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