Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 14 Parkinson's papers of 118 | 0.64 |
| pathways Reactome | 2 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 3114
Sealed predictions
- KCNJ6 in dopamine neurons, braak-0.33 (p 0.387) → -0.09 (p 0.820)receipt 3122
In the sealed studies
Swarm cases
receipt 3122: KCNJ6 in dopamine neurons, braak
- power
- full sample -0.20 (p 0.418, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.493, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.389, n 18). could be the mix.
- skeptic
- leave-one-out range -0.35 to -0.11, sign flips 0; without severely affected donors -0.20 (p 0.418, n 18). fragile.
- cell type
- strongest in OPCs: -0.72 (p 7.4e-4, n 18) vs -0.20 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for KCNJ6 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up KCNJ6 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.45 p 0.110 (needs p < 6.1e-4)
Receipts
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