Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

KCNIP3

potassium voltage-gated channel interacting protein 3

translation score 0.54, read 2026-10-25; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in oligodendrocyte progenitor cells (103 nCPM)1.00
chemistry
Open Targets		reachable by antibody0.45
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 9934

Sealed predictions

  1. KCNIP3 in dopamine neurons, braak-0.29 (p 0.443) → -0.48 (p 0.195)receipt 9943
  2. KCNIP3 in oligodendrocytes, braak-0.44 (p 0.238) → -0.03 (p 0.946)receipt 9942

Swarm cases

receipt 9943: KCNIP3 in dopamine neurons, braak

power
full sample -0.36 (p 0.148, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.148, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.028, n 18). not the mix.
skeptic
leave-one-out range -0.49 to -0.27, sign flips 0; without severely affected donors -0.36 (p 0.148, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNIP3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9942: KCNIP3 in oligodendrocytes, braak

power
full sample -0.47 (p 0.047, n 18), 95% CI -0.77 to -0.01. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.48 (p 0.043, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.44 (p 0.070, n 18). could be the mix.
skeptic
leave-one-out range -0.61 to -0.41, sign flips 0; without severely affected donors -0.47 (p 0.047, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNIP3 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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