Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

KCNA6

potassium voltage-gated channel subfamily A member 6

translation score 0.54, read 2026-10-21; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.06 from other evidence0.00
cell type
Human Protein Atlas
not detected in single-cell data0.00
chemistry
Open Targets
compounds already reach it: tedisamil, amifampridine phosphate, guanidine hydrochloride +31.00
trials
ClinicalTrials.gov
6 Parkinson's trials, 1 stopped0.87
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly dopamine synapse1.00

No case: the score is under the bar. Receipt 4726

Sealed predictions

  1. KCNA6 in dopamine neurons, braakn/a → n/areceipt 4732

Swarm cases

receipt 4732: KCNA6 in dopamine neurons, braak

cell type
KCNA6 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for KCNA6 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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