Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.21 (overall 0.13) | 0.21 |
| cell type Human Protein Atlas | enriched in the midbrain (2 nTPM), where the nigral dopamine neurons sit | 0.90 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2277
Sealed predictions
- IRX4 in dopamine neurons, braak-0.69 (p 0.038) → -0.29 (p 0.456)receipt 2283
Swarm cases
receipt 2283: IRX4 in dopamine neurons, braak
- power
- full sample -0.47 (p 0.050, n 18), 95% CI -0.77 to -0.00. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.45 (p 0.062, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.49 (p 0.039, n 18). not the mix.
- skeptic
- leave-one-out range -0.63 to -0.40, sign flips 0; without severely affected donors -0.47 (p 0.050, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IRX4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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