Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: bms-754807, insulin susp isophane recombinant human, insulin glargine +18 | 0.90 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 3 Parkinson's papers of 1,735 | 0.82 |
| pathways Reactome | 6 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 2436
Sealed predictions
- INSR in dopamine neurons, braak+0.22 (p 0.565) → -0.18 (p 0.648)receipt 2443
Swarm cases
receipt 2443: INSR in dopamine neurons, braak
- power
- full sample -0.04 (p 0.881, n 18), 95% CI -0.50 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.06 (p 0.800, n 18). could be the mix.
- skeptic
- leave-one-out range -0.16 to +0.08, sign flips 4; without severely affected donors -0.04 (p 0.881, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for INSR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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