Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 40 | 0.82 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8397
Sealed predictions
- INPP5K in dopamine neurons, braak-0.39 (p 0.306) → -0.07 (p 0.855)receipt 8403
Swarm cases
receipt 8403: INPP5K in dopamine neurons, braak
- power
- full sample -0.26 (p 0.298, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.201, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.298, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for INPP5K in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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