Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (78 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 6 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 13 Parkinson's papers of 4,182 | 0.65 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12211
Sealed predictions
- INA in dopamine neurons, braak+0.75 (p 0.021) → -0.24 (p 0.539)receipt 12217
Swarm cases
receipt 12217: INA in dopamine neurons, braak
- power
- full sample +0.16 (p 0.521, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.19 (p 0.460, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.26 (p 0.298, n 18). could be the mix.
- skeptic
- leave-one-out range +0.05 to +0.33, sign flips 0; without severely affected donors +0.16 (p 0.521, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for INA in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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