Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

IL5

interleukin 5

translation score 0.45, read 2026-10-21; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (epicardial cells)0.10
chemistry
Open Targets
compounds already reach it: mepolizumab, reslizumab, depemokimab0.90
trials
ClinicalTrials.gov
4 Parkinson's trials, 1 stopped0.80
literature
PubMed
14 Parkinson's papers of 18,1730.64
pathways
Reactome
4 pathways; mostly immune signalling0.90

No case: the score is under the bar. Receipt 5442

Sealed predictions

  1. IL5 in dopamine neurons, braakn/a → n/areceipt 5449

Swarm cases

receipt 5449: IL5 in dopamine neurons, braak

cell type
IL5 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL5 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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