Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

IL36R

interleukin 36 receptor

translation score 0.54, read 2026-10-23; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
genetic association 0.04 (overall 0.02)0.04
cell type
Human Protein Atlas
not in the Protein Atlas0.00
chemistry
Open Targets
compounds already reach it: spesolimab, imsidolimab0.90
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
2 pathways; mostly immune signalling0.90

No case: the score is under the bar. Receipt 7421

Sealed predictions

  1. IL36R in dopamine neurons, braakn/a → n/areceipt 7429

Swarm cases

receipt 7429: IL36R in dopamine neurons, braak

cell type
IL36R is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL36R in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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