Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

IL31

interleukin 31

translation score 0.46, read 2026-10-29; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (epicardial cells)0.10
chemistry
Open Targets
reachable by antibody0.45
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 1,0130.85
pathways
Reactome
1 pathway; mostly immune signalling0.90

No case: the score is under the bar. Receipt 14384

Sealed predictions

  1. IL31 in dopamine neurons, braakn/a → n/areceipt 14392

Swarm cases

receipt 14392: IL31 in dopamine neurons, braak

cell type
IL31 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL31 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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