parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in bergmann glia	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 7969

receipt 7977: IL17D in dopamine neurons, braak

power: full sample -0.32 (p 0.201, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.39 (p 0.109, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.107, n 18). could be the mix.
skeptic: leave-one-out range -0.48 to -0.23, sign flips 0; without severely affected donors -0.32 (p 0.201, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IL17D in dopamine neurons.

case closed: nothing better to follow up.

receipt 7976: IL17D in astrocytes, braak

power: full sample -0.32 (p 0.198, n 18), 95% CI -0.68 to +0.17. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.33 (p 0.179, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.33 (p 0.185, n 18). could be the mix.
skeptic: leave-one-out range -0.50 to -0.22, sign flips 0; without severely affected donors -0.32 (p 0.198, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IL17D in astrocytes.

case closed: nothing better to follow up.

loading the receipts