Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (early spermatids) | 0.10 |
| chemistry Open Targets | reachable by antibody: cintredekin besudotox | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 166 | 0.91 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 13505
Sealed predictions
- IL13RA2 in dopamine neurons, braak-0.14 (p 0.714) → +0.77 (p 0.015)receipt 13512
Swarm cases
receipt 13512: IL13RA2 in dopamine neurons, braak
- power
- full sample +0.17 (p 0.504, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.30 (p 0.221, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.30 (p 0.221, n 18). could be the mix.
- skeptic
- leave-one-out range +0.07 to +0.31, sign flips 0; without severely affected donors +0.17 (p 0.504, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL13RA2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts