Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in esophageal apical cells | 0.75 |
| chemistry Open Targets | reachable by antibody: cintredekin besudotox | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 124 | 0.82 |
| pathways Reactome | 1 pathway; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 4672
Sealed predictions
- IL13RA1 in dopamine neurons, braak+0.11 (p 0.787) → +0.29 (p 0.449)receipt 4679
- IL13RA1 in microglia, braak+0.66 (p 0.054) → +0.05 (p 0.893)receipt 4678
Swarm cases
receipt 4679: IL13RA1 in dopamine neurons, braak
- power
- full sample +0.14 (p 0.567, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.27 (p 0.281, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.315, n 18). could be the mix.
- skeptic
- leave-one-out range +0.03 to +0.31, sign flips 0; without severely affected donors +0.14 (p 0.567, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL13RA1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 4678: IL13RA1 in microglia, braak
- power
- full sample +0.38 (p 0.120, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.38 (p 0.120, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.38 (p 0.123, n 18). could be the mix.
- skeptic
- leave-one-out range +0.30 to +0.49, sign flips 0; without severely affected donors +0.38 (p 0.120, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL13RA1 in microglia.
case closed: nothing better to follow up.
Receipts
loading the receipts