Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.11 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (monocytes) | 0.10 |
| chemistry Open Targets | compounds already reach it: sch-708980 | 0.81 |
| trials ClinicalTrials.gov | 21 Parkinson's trials, 2 stopped | 0.92 |
| literature PubMed | 324 Parkinson's papers of 88,223 | 0.24 |
| pathways Reactome | 7 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 2378
Sealed predictions
- IL10 in dopamine neurons, braak-0.66 (p 0.053) → -0.38 (p 0.311)receipt 2386
Swarm cases
receipt 2386: IL10 in dopamine neurons, braak
- power
- full sample -0.47 (p 0.047, n 18), 95% CI -0.77 to -0.01. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.41 (p 0.091, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.101, n 18). could be the mix.
- skeptic
- leave-one-out range -0.61 to -0.41, sign flips 0; without severely affected donors -0.47 (p 0.047, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL10 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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