Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

IGHE

immunoglobulin heavy constant epsilon

translation score 0.54, read 2026-10-30; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas
group enriched outside the brain (oocytes)0.10
chemistry
Open Targets
compounds already reach it: medi-4212, talizumab, ligelizumab +20.90
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
6 pathways; mostly immune signalling0.90

No case: the score is under the bar. Receipt 14765

Sealed predictions

  1. IGHE in dopamine neurons, braakn/a → n/areceipt 14772

Swarm cases

receipt 14772: IGHE in dopamine neurons, braak

cell type
IGHE is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IGHE in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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