parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	a small-molecule pocket: interferon gamma-1b	0.60
trials ClinicalTrials.gov	3 Parkinson's trials, 1 stopped	0.73
literature PubMed	3 Parkinson's papers of 596	0.82
pathways Reactome	4 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 10505

IFNGR1 in microglia, braak-0.16 (p 0.685) → -0.02 (p 0.964)receipt 10512
IFNGR1 in dopamine neurons, braak+0.20 (p 0.615) → +0.08 (p 0.838)receipt 10513

receipt 10513: IFNGR1 in dopamine neurons, braak

power: full sample +0.16 (p 0.515, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.16 (p 0.526, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.14 (p 0.567, n 18). could be the mix.
skeptic: leave-one-out range +0.09 to +0.32, sign flips 0; without severely affected donors +0.16 (p 0.515, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IFNGR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10512: IFNGR1 in microglia, braak

power: full sample -0.02 (p 0.942, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.814, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.08 (p 0.767, n 18). could be the mix.
skeptic: leave-one-out range -0.15 to +0.10, sign flips 7; without severely affected donors -0.02 (p 0.942, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for IFNGR1 in microglia.

case closed: nothing better to follow up.

loading the receipts